Development and Evaluation of Gastroretentive Floating Microspheres of Valsartan.
نویسندگان
چکیده
منابع مشابه
Floating Microspheres: Recent Trends in the Development of Gastroretentive Floating Drug Delivery System
Oral controlled release systems are designed to release the drug in-vivo with prediction so as to increase efficacy, minimize adverse effects and increase bioavailability of drugs. Floating drug delivery systems (FDDSs) are expected to remain buoyant in a lasting way upon the gastric contents. The various buoyant preparations include hollow microspheres, granules, powders, tablets, capsules, pi...
متن کاملDevelopment and evaluation of gastroretentive norfloxacin floating tablets.
Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxypropyl methylcellulose (HPMC K4M, HPMC K100M) and xanthan gum. Tablets were evaluated for their physical characteristics, viz., hardness, thickness, friability, and mass vari...
متن کاملDevelopment and Evaluation of Floating Microspheres of Curcumin
Purpose: To prepare and evaluate floating microspheres of curcumin for prolonged gastric residence time and increased drug bioavailability. Methods: Floating microsphere were prepared by emulsion solvent diffusion method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. Ethanol/dichloromethane blend was used as solvent in a ratio of 1:...
متن کاملHollow microspheres for gastroretentive floating- pulsatile drug delivery: preparation and in vitro evaluation.
PURPOSE A multiparticular floating-pulsatile drug delivery system was developed for time and site specific drug release of piroxicam. A blend of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in the upper GI tract after a definite time period. METHODS Hollow microspheres were prepared by the emulsion solvent diffusion method usin...
متن کاملPreparation and evaluation of gastroretentive floating tablets of Silymarin.
The present study performed by preparation and evaluation of floating tablets of Silymarin as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose (HPMC) K 4M, K 15M, psyllium husk, swelling agent as crospovidone and microcrystalline cellulose and gas generating agent like sodium bicarbonate ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Current Pharma Research
سال: 2015
ISSN: 2230-7834,2230-7842
DOI: 10.33786/jcpr.2015.v05i03.006